Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Summary: How chromosome organization is related to genome function remains poorly understood.Cohesin, loop extrusion, and CCCTC-binding factor (CTCF) have been proposed to create topologically associating domains (TADs) to regulate gene expression.Here, we examine chromosome conformation in embryonic stem cells lacking cohesin and find, as in other